Assay Detail
Binding
CHEMBL2155761
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TYK2
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Non-receptor tyrosine-protein kinase TYK2 (CHEMBL3553) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.12 | 8.38 |
| IC50 | 1 | 6.94 | 6.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2152297 | — | — | 1 | 8.38 |
| CHEMBL2152300 | — | — | 1 | 8.33 |
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 8.11 |
| CHEMBL2152302 | — | — | 1 | 7.15 |
| CHEMBL2152305 | — | — | 1 | 7.07 |
| CHEMBL2152303 | — | — | 1 | 7.05 |
| CHEMBL1795071 | RUXOLITINIB PHOSPHATE | 4.0 | 1 | 6.94 |
| CHEMBL2152299 | — | — | 1 | 6.80 |
| CHEMBL2152301 | — | — | 1 | 6.60 |
| CHEMBL2152304 | — | — | 1 | 6.27 |
| CHEMBL2152298 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2152297 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL2152300 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL221959 | TOFACITINIB | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL2152302 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL2152305 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL2152303 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL1795071 | RUXOLITINIB PHOSPHATE | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL2152299 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL2152301 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL2152304 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL2152298 | — | Ki | = | 3500.0 | nM | 5.46 |