Assay Detail
Functional
CHEMBL2156128
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Immunosuppressive activity in mouse lymphocytes assessed as alloantigen-induced T cell proliferation by mixed lymphocyte reaction assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Lymphocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship and pharmacokinetic studies of sotrastaurin (AEB071), a promising novel medicine for prevention of graft rejection and treatment of psoriasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.67 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2153748 | — | — | 1 | 7.14 |
| CHEMBL2151411 | — | — | 1 | 7.11 |
| CHEMBL568580 | — | — | 1 | 6.91 |
| CHEMBL565612 | SOTRASTAURIN | 2.0 | 1 | 6.82 |
| CHEMBL2151415 | — | — | 1 | 6.42 |
| CHEMBL2153747 | — | — | 1 | 6.24 |
| CHEMBL1996510 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2153748 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL2151411 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL568580 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL565612 | SOTRASTAURIN | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2151415 | — | IC50 | = | 378.0 | nM | 6.42 |
| CHEMBL2153747 | — | IC50 | = | 575.0 | nM | 6.24 |
| CHEMBL1996510 | — | IC50 | = | 854.0 | nM | 6.07 |