Assay Detail
Functional
CHEMBL2156129
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Immunosuppressive activity in human lymphocytes assessed as alloantigen-induced T cell proliferation by mixed lymphocyte reaction assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Lymphocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship and pharmacokinetic studies of sotrastaurin (AEB071), a promising novel medicine for prevention of graft rejection and treatment of psoriasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.43 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2151411 | — | — | 1 | 7.82 |
| CHEMBL568580 | — | — | 1 | 7.60 |
| CHEMBL565612 | SOTRASTAURIN | 2.0 | 1 | 7.43 |
| CHEMBL2153748 | — | — | 1 | 7.43 |
| CHEMBL1996510 | — | — | 1 | 7.29 |
| CHEMBL2151415 | — | — | 1 | 7.00 |
| CHEMBL2153747 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2151411 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL568580 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL565612 | SOTRASTAURIN | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL2153748 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL1996510 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL2151415 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL2153747 | — | IC50 | - | — | - |