Assay Detail
Binding
CHEMBL2156217
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]naloxone from MOR in rat brain homogenates by liquid scintillation counting
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Superpotent [Dmt¹] dermorphin tetrapeptides containing the 4-aminotetrahydro-2-benzazepin-3-one scaffold with mixed μ/δ opioid receptor agonistic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.74 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2151734 | — | — | 1 | 9.52 |
| CHEMBL2151735 | — | — | 1 | 9.02 |
| CHEMBL409225 | — | — | 1 | 7.68 |
| CHEMBL260120 | — | — | 1 | - |
| CHEMBL1834247 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2151734 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL2151735 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL409225 | — | IC50 | = | 20.8 | nM | 7.68 |
| CHEMBL260120 | — | IC50 | = | 28.1 | nM | - |
| CHEMBL1834247 | — | IC50 | - | — | - |