Assay Detail
Functional
CHEMBL2156331
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Agonist activity at MOR/DOR in in NMRI mouse frontal cortex assessed as reduction in spinal cord network activity by electrophysiology assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Frontal cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Superpotent [Dmt¹] dermorphin tetrapeptides containing the 4-aminotetrahydro-2-benzazepin-3-one scaffold with mixed μ/δ opioid receptor agonistic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.25 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL409225 | — | — | 1 | 6.25 |
| CHEMBL260120 | — | — | 1 | - |
| CHEMBL2151734 | — | — | 1 | - |
| CHEMBL2151735 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL409225 | — | EC50 | = | 567.0 | nM | 6.25 |
| CHEMBL260120 | — | EC50 | = | 0.005 | nM | - |
| CHEMBL2151734 | — | EC50 | = | 0.000129 | nM | - |
| CHEMBL2151735 | — | EC50 | = | 1.61e-06 | nM | - |