Assay Detail
Binding
CHEMBL2156544
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Inhibition of MDM2 binding to p53
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel dihydroimidazothiazole derivatives as p53-MDM2 protein-protein interaction inhibitors: synthesis, biological evaluation and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.26 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191334 | NUTLIN-3 | — | 1 | 7.05 |
| CHEMBL407632 | NUTLIN-2 | — | 1 | 6.85 |
| CHEMBL2152332 | — | — | 1 | 4.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL407632 | NUTLIN-2 | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2152332 | — | IC50 | = | 13600.0 | nM | 4.87 |