Assay Detail
Binding
CHEMBL2157253
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kdelta-mediated AKT phosphorylation in B cells in presence of human serum
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | B |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potent and selective inhibitors of PI3Kδ: obtaining isoform selectivity from the affinity pocket and tryptophan shelf.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.97 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2152768 | — | — | 1 | 7.40 |
| CHEMBL2152769 | — | — | 1 | 7.26 |
| CHEMBL2152772 | — | — | 1 | 7.17 |
| CHEMBL2152771 | — | — | 1 | 6.84 |
| CHEMBL2152773 | — | — | 1 | 6.84 |
| CHEMBL2152770 | — | — | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2152768 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2152769 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL2152772 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL2152771 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL2152773 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL2152770 | — | IC50 | = | 480.0 | nM | 6.32 |