Compound Detail
CHEMBL2152772
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Basic Information
| ChEMBL ID | CHEMBL2152772 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WWKWKMNWCVHWGF-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
448.5
MW (Da)
2.98
ALogP
7
HBA
1
HBD
79.4
PSA (Ų)
0.51
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform CHEMBL3130 | IC50 | 7.92 | 7.545 | 12.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | IC50 | = | 12.0 | nM | 7.92 | Inhibition of PI3K p110delta using PIP2 as substrate assessed as PIP3 formation ... | 22672799 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | IC50 | = | 67.0 | nM | 7.17 | Inhibition of PI3Kdelta-mediated AKT phosphorylation in B cells in presence of h... | 22672799 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22672799 | 10.1016/j.bmcl.2012.05.027 | Unchecked | 3 |
| 22672799 | 10.1016/j.bmcl.2012.05.027 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 2 |
Data from ChEMBL 36 via Core Engine