Assay Detail
Binding
CHEMBL2157807
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to alpha7 nAChR
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL2492) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and development of α7 nicotinic acetylcholine receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 7.84 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2151569 | — | — | 1 | 9.62 |
| CHEMBL597241 | — | — | 1 | 9.00 |
| CHEMBL378471 | — | — | 1 | 8.80 |
| CHEMBL378349 | — | — | 1 | 8.68 |
| CHEMBL603052 | — | — | 1 | 8.49 |
| CHEMBL56564 | TROPISETRON | 3.0 | 1 | 8.16 |
| CHEMBL2151444 | — | — | 1 | 8.08 |
| CHEMBL192704 | — | — | 1 | 8.05 |
| CHEMBL2151445 | — | — | 1 | 8.02 |
| CHEMBL379302 | — | — | 1 | 7.90 |
| CHEMBL125069 | — | — | 1 | 7.89 |
| CHEMBL611082 | — | — | 1 | 7.65 |
| CHEMBL2113232 | — | — | 1 | 7.55 |
| CHEMBL597843 | — | — | 1 | 7.52 |
| CHEMBL192237 | — | — | 1 | 7.12 |
| CHEMBL362962 | — | — | 1 | 7.10 |
| CHEMBL372419 | — | — | 1 | 6.78 |
| CHEMBL193016 | — | — | 1 | 6.47 |
| CHEMBL563848 | — | — | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2151569 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL597241 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL378471 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL378349 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL603052 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL56564 | TROPISETRON | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL2151444 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL192704 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL2151445 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL379302 | — | Ki | = | 12.5 | nM | 7.90 |
| CHEMBL125069 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL611082 | — | Ki | = | 22.5 | nM | 7.65 |
| CHEMBL2113232 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL597843 | — | Ki | = | 30.3 | nM | 7.52 |
| CHEMBL192237 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL362962 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL372419 | — | Ki | = | 167.0 | nM | 6.78 |
| CHEMBL193016 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL563848 | — | Ki | = | 739.0 | nM | 6.13 |