Compound Detail
CHEMBL362962
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Basic Information
| ChEMBL ID | CHEMBL362962 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SRKWHAJRJDBXCG-CYBMUJFWSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
264.4
MW (Da)
2.17
ALogP
4
HBA
0
HBD
32.8
PSA (Ų)
0.78
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 7.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Neuronal acetylcholine receptor subunit alpha-7 CHEMBL2492 | Ki | 7.1 | 7.1 | 80.0 | 1 |
| Neuronal acetylcholine receptor subunit alpha-7 CHEMBL4980 | Ki | 7.1 | 7.1 | 80.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Neuronal acetylcholine receptor subunit alpha-7 | Ki | = | 80.0 | nM | 7.1 | Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine re... | 15801858 |
| Neuronal acetylcholine receptor subunit alpha-7 | Ki | = | 80.0 | nM | 7.1 | Binding affinity to alpha7 nAChR | 21919481 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15801858 | 10.1021/jm049188d | Neuronal acetylcholine receptor subunit alpha-7 | 1 |
| 21919481 | 10.1021/jm2007672 | Neuronal acetylcholine receptor subunit alpha-7 | 1 |
| - | 10.6019/CHEMBL3301361 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine