Assay Detail
Functional
CHEMBL2160281
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Cytotoxicity against human NAMALWA cells assessed as cell survival after 72 hrs in presence of bovine alkaline phosphatase by clonogenic assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NAMALVA |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 10.56 | 10.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2158591 | — | — | 1 | 10.60 |
| CHEMBL2158590 | — | — | 1 | 10.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2158591 | — | IC50 | = | 0.025 | nM | 10.60 |
| CHEMBL2158590 | — | IC50 | = | 0.03 | nM | 10.52 |