Assay Detail
Binding
CHEMBL2160642
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Inhibition at human recombinant POP
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Virtual screening and computational optimization for the discovery of covalent prolyl oligopeptidase inhibitors with activity in human cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.82 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2159749 | — | — | 1 | 6.82 |
| CHEMBL2159748 | — | — | 1 | - |
| CHEMBL2159745 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2159749 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2159748 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL2159745 | — | IC50 | < | 50.0 | nM | - |