Assay Detail
Binding
CHEMBL2160769
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Inhibition of rat small intestinal isomaltase after 30 mins by glucose-oxidase method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Role of the side chain stereochemistry in the α-glucosidase inhibitory activity of kotalanol, a potent natural α-glucosidase inhibitor. Part 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.03 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1208974 | SALACINOL | — | 1 | 5.89 |
| CHEMBL2159763 | — | — | 1 | 5.80 |
| CHEMBL1093264 | KOTALANOL | — | 1 | 5.24 |
| CHEMBL2159632 | — | — | 1 | 5.19 |
| CHEMBL2159631 | — | — | 1 | 4.96 |
| CHEMBL2159633 | — | — | 1 | 4.80 |
| CHEMBL2159634 | — | — | 1 | 4.80 |
| CHEMBL2159635 | — | — | 1 | 4.70 |
| CHEMBL2159636 | — | — | 1 | 4.68 |
| CHEMBL2159637 | — | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1208974 | SALACINOL | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2159763 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1093264 | KOTALANOL | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL2159632 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL2159631 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2159633 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL2159634 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL2159635 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL2159636 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL2159637 | — | IC50 | = | 58000.0 | nM | 4.24 |