Assay Detail
Binding
CHEMBL2160770
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Inhibition of rat small intestinal sucrase after 30 mins by glucose-oxidase method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Role of the side chain stereochemistry in the α-glucosidase inhibitory activity of kotalanol, a potent natural α-glucosidase inhibitor. Part 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.97 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1093264 | KOTALANOL | — | 1 | 6.12 |
| CHEMBL1208974 | SALACINOL | — | 1 | 5.80 |
| CHEMBL2159632 | — | — | 1 | 4.50 |
| CHEMBL2159637 | — | — | 1 | 4.26 |
| CHEMBL2159763 | — | — | 1 | 4.17 |
| CHEMBL2159633 | — | — | 1 | - |
| CHEMBL2159631 | — | — | 1 | - |
| CHEMBL2159636 | — | — | 1 | - |
| CHEMBL2159635 | — | — | 1 | - |
| CHEMBL2159634 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1093264 | KOTALANOL | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL1208974 | SALACINOL | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2159632 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL2159637 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL2159763 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL2159633 | — | IC50 | = | 214000.0 | nM | - |
| CHEMBL2159631 | — | IC50 | = | 136000.0 | nM | - |
| CHEMBL2159636 | — | IC50 | > | 236000.0 | nM | - |
| CHEMBL2159635 | — | IC50 | > | 236000.0 | nM | - |
| CHEMBL2159634 | — | IC50 | > | 236000.0 | nM | - |