Assay Detail
Binding
CHEMBL2161972
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Inhibition of HePTP expressed in Escherichia coli BL21 using pNPP substrate
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 7 (CHEMBL2219) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.87 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2159933 | — | — | 1 | 5.10 |
| CHEMBL2159726 | — | — | 1 | 5.10 |
| CHEMBL2159725 | — | — | 1 | 5.05 |
| CHEMBL1713374 | — | — | 1 | 5.00 |
| CHEMBL2159929 | — | — | 1 | 4.92 |
| CHEMBL2159934 | — | — | 1 | 4.82 |
| CHEMBL2159932 | — | — | 1 | 4.80 |
| CHEMBL2159928 | — | — | 1 | 4.75 |
| CHEMBL1721448 | — | — | 1 | 4.70 |
| CHEMBL2159930 | — | — | 1 | 4.70 |
| CHEMBL2159931 | — | — | 1 | 4.66 |
| CHEMBL1710150 | — | — | 1 | - |
| CHEMBL2159937 | — | — | 1 | - |
| CHEMBL2159949 | — | — | 1 | - |
| CHEMBL2158022 | — | — | 1 | - |
| CHEMBL2159948 | — | — | 1 | - |
| CHEMBL2159946 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2159933 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL2159726 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL2159725 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL1713374 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2159929 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2159934 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL2159932 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL2159928 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1721448 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL2159930 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL2159931 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL1710150 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL2159937 | — | IC50 | > | 75000.0 | nM | - |
| CHEMBL2159949 | — | IC50 | > | 75000.0 | nM | - |
| CHEMBL2158022 | — | IC50 | > | 75000.0 | nM | - |
| CHEMBL2159948 | — | IC50 | > | 75000.0 | nM | - |
| CHEMBL2159946 | — | IC50 | > | 75000.0 | nM | - |