Assay Detail
Binding
CHEMBL2161973
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LYP expressed in Escherichia coli BL21 using increasing levels of ARLIED-NEpYTAREG substrate
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 22 (CHEMBL2889) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.10 | 5.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2159938 | — | — | 1 | 5.67 |
| CHEMBL2159935 | — | — | 1 | 5.51 |
| CHEMBL2159940 | — | — | 1 | 5.09 |
| CHEMBL2159939 | — | — | 1 | 4.96 |
| CHEMBL1721448 | — | — | 1 | 4.90 |
| CHEMBL260920 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2159938 | — | Ki | = | 2160.0 | nM | 5.67 |
| CHEMBL2159935 | — | Ki | = | 3070.0 | nM | 5.51 |
| CHEMBL2159940 | — | Ki | = | 8070.0 | nM | 5.09 |
| CHEMBL2159939 | — | Ki | = | 11040.0 | nM | 4.96 |
| CHEMBL1721448 | — | Ki | = | 12480.0 | nM | 4.90 |
| CHEMBL260920 | — | Ki | = | 33870.0 | nM | 4.47 |