Assay Detail
Binding
CHEMBL2162063
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Inhibition of human recombinant BChE using acetylthiocholine as substrate
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and bioevaluation of benzamides: novel acetylcholinesterase inhibitors with multi-functions on butylcholinesterase, Aβ aggregation, and β-secretase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.00 | 8.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 8.06 |
| CHEMBL2159662 | — | — | 1 | 7.26 |
| CHEMBL2159659 | — | — | 1 | 7.25 |
| CHEMBL2159664 | — | — | 1 | 7.18 |
| CHEMBL2159660 | — | — | 1 | 7.09 |
| CHEMBL2159663 | — | — | 1 | 7.03 |
| CHEMBL2159657 | — | — | 1 | 7.01 |
| CHEMBL2159661 | — | — | 1 | 7.00 |
| CHEMBL2159658 | — | — | 1 | 6.78 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 6.72 |
| CHEMBL2159656 | — | — | 1 | 5.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | Ki | = | 8.72 | nM | 8.06 |
| CHEMBL2159662 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL2159659 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL2159664 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL2159660 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL2159663 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL2159657 | — | Ki | = | 97.0 | nM | 7.01 |
| CHEMBL2159661 | — | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL2159658 | — | Ki | = | 166.0 | nM | 6.78 |
| CHEMBL659 | GALANTAMINE | Ki | = | 192.47 | nM | 6.72 |
| CHEMBL2159656 | — | Ki | = | 2360.0 | nM | 5.63 |