Assay Detail
Binding
CHEMBL2162208
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Inhibition of HIV-1 reverse transcriptase using 0.05 ug/mL of Poly(rA).p(dT) (12 to 18) as substrate after 30 mins by single point PCR assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Inhibition of therapeutically important polymerases with high affinity bis-intercalators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.48 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2159008 | — | — | 1 | 8.31 |
| CHEMBL2159009 | — | — | 1 | 8.04 |
| CHEMBL2159010 | — | — | 1 | 7.98 |
| CHEMBL2159003 | — | — | 1 | 7.97 |
| CHEMBL2159011 | — | — | 1 | 7.65 |
| CHEMBL2159012 | — | — | 1 | 7.51 |
| CHEMBL2159014 | ACRIDINE DIMER | — | 1 | 6.66 |
| CHEMBL48166 | HOMIDIUM | 2.0 | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2159008 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL2159009 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL2159010 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL2159003 | — | IC50 | = | 10.8 | nM | 7.97 |
| CHEMBL2159011 | — | IC50 | = | 22.3 | nM | 7.65 |
| CHEMBL2159012 | — | IC50 | = | 30.7 | nM | 7.51 |
| CHEMBL2159014 | ACRIDINE DIMER | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL48166 | HOMIDIUM | IC50 | = | 2100.0 | nM | 5.68 |