Compound Detail
CHEMBL48166
HOMIDIUM 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL48166 |
| Name | HOMIDIUM |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | QTANTQQOYSUMLC-UHFFFAOYSA-O |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
10
Publications
6
Known Names
Molecular Properties
314.4
MW (Da)
4.13
ALogP
2
HBA
2
HBD
55.9
PSA (Ų)
0.33
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
IC50 4 meas. best 5.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Human immunodeficiency virus type 1 reverse transcriptase CHEMBL247 | IC50 | 5.75 | 5.6967 | 1800.0 | 3 |
| Unchecked CHEMBL612545 | IC50 | 5.48 | 5.48 | 3300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Human immunodeficiency virus type 1 reverse transcriptase | IC50 | = | 1800.0 | nM | 5.75 | Inhibition of HIV-1 reverse transcriptase using 0.5 ug/mL of Poly(rA).p(dT) (12 ... | 22695131 |
| Human immunodeficiency virus type 1 reverse transcriptase | IC50 | = | 2100.0 | nM | 5.68 | Inhibition of HIV-1 reverse transcriptase using 0.05 ug/mL of Poly(rA).p(dT) (12... | 22695131 |
| Human immunodeficiency virus type 1 reverse transcriptase | IC50 | = | 2200.0 | nM | 5.66 | Inhibition of HIV-1 reverse transcriptase using 25 ug/mL of Poly(rA).p(dT) (12 t... | 22695131 |
| Unchecked | IC50 | = | 3300.0 | nM | 5.48 | Inhibition of telomerase | 22695131 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 4 |
| 22695131 | 10.1016/j.bmcl.2012.05.041 | Human immunodeficiency virus type 1 reverse transcriptase | 3 |
| - | 10.6019/CHEMBL4495565 | Vero C1008 | 2 |
| - | 10.6019/CHEMBL4495565 | ADMET | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 22695131 | 10.1016/j.bmcl.2012.05.041 | Unchecked | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
| 38283226 | 10.1039/d3md00483j | Escherichia coli | 1 |
| 38318365 | 10.1016/j.isci.2024.108907 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 1 |
Data from ChEMBL 36 via Core Engine