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Assay Detail

CHEMBL2162371

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HIV 1 in HeLa-CD4/CCR5 cells assessed as inhibition of viral infectivity after 48 hrs by MAGI assay
ChEMBL ↗
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type MAGI-CCR5
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Structure-activity relationship study of pyrimido[1,2-c][1,3]benzothiazin-6-imine derivatives for potent anti-HIV agents.
Mizuhara T, Oishi S, Ohno H, Shimura K, Matsuoka M, Fujii N.
Bioorg Med Chem (2012) 20 : 6434 -6441
PubMed 23022280 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 50 6.30 6.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2159032 — — 1 6.82
CHEMBL2158981 — — 1 6.82
CHEMBL2158979 — — 1 6.70
CHEMBL2158965 — — 1 6.70
CHEMBL2159023 — — 1 6.70
CHEMBL2158966 — — 1 6.66
CHEMBL2159038 — — 1 6.62
CHEMBL2159044 — — 1 6.62
CHEMBL2158962 — — 1 6.62
CHEMBL2158976 — — 1 6.60
CHEMBL2158970 — — 1 6.60
CHEMBL2158964 — — 1 6.60
CHEMBL2159017 — — 1 6.60
CHEMBL2159022 — — 1 6.58
CHEMBL2158967 — — 1 6.58
CHEMBL2159016 — — 1 6.58
CHEMBL2159037 — — 1 6.57
CHEMBL2158977 — — 1 6.50
CHEMBL2159036 — — 1 6.50
CHEMBL2159033 — — 1 6.50
CHEMBL2159024 — — 1 6.42
CHEMBL2158980 — — 1 6.41
CHEMBL2159025 — — 1 6.41
CHEMBL2159035 — — 1 6.39
CHEMBL2158968 — — 1 6.38
CHEMBL2158973 — — 1 6.36
CHEMBL595227 — — 1 6.36
CHEMBL2159040 — — 1 6.36
CHEMBL2159020 — — 1 6.35
CHEMBL2159041 — — 1 6.34

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2159032 — EC50 = 150.0 nM 6.82
CHEMBL2158981 — EC50 = 150.0 nM 6.82
CHEMBL2158979 — EC50 = 200.0 nM 6.70
CHEMBL2158965 — EC50 = 200.0 nM 6.70
CHEMBL2159023 — EC50 = 200.0 nM 6.70
CHEMBL2158966 — EC50 = 220.0 nM 6.66
CHEMBL2159038 — EC50 = 240.0 nM 6.62
CHEMBL2159044 — EC50 = 240.0 nM 6.62
CHEMBL2158962 — EC50 = 240.0 nM 6.62
CHEMBL2158976 — EC50 = 250.0 nM 6.60
CHEMBL2158970 — EC50 = 250.0 nM 6.60
CHEMBL2158964 — EC50 = 250.0 nM 6.60
CHEMBL2159017 — EC50 = 250.0 nM 6.60
CHEMBL2159016 — EC50 = 260.0 nM 6.58
CHEMBL2159022 — EC50 = 260.0 nM 6.58
CHEMBL2158967 — EC50 = 260.0 nM 6.58
CHEMBL2159037 — EC50 = 270.0 nM 6.57
CHEMBL2158977 — EC50 = 320.0 nM 6.50
CHEMBL2159036 — EC50 = 320.0 nM 6.50
CHEMBL2159033 — EC50 = 320.0 nM 6.50
CHEMBL2159024 — EC50 = 380.0 nM 6.42
CHEMBL2158980 — EC50 = 390.0 nM 6.41
CHEMBL2159025 — EC50 = 390.0 nM 6.41
CHEMBL2159035 — EC50 = 410.0 nM 6.39
CHEMBL2158968 — EC50 = 420.0 nM 6.38
CHEMBL2158973 — EC50 = 440.0 nM 6.36
CHEMBL2159040 — EC50 = 440.0 nM 6.36
CHEMBL595227 — EC50 = 440.0 nM 6.36
CHEMBL2159020 — EC50 = 450.0 nM 6.35
CHEMBL2159041 — EC50 = 460.0 nM 6.34
CHEMBL2158978 — EC50 = 480.0 nM 6.32
CHEMBL2159021 — EC50 = 540.0 nM 6.27
CHEMBL2159042 — EC50 = 550.0 nM 6.26
CHEMBL2159039 — EC50 = 810.0 nM 6.09
CHEMBL2159026 — EC50 = 1170.0 nM 5.93
CHEMBL2159028 — EC50 = 1190.0 nM 5.92
CHEMBL2159027 — EC50 = 1260.0 nM 5.90
CHEMBL2159034 — EC50 = 1350.0 nM 5.87
CHEMBL2158972 — EC50 = 1450.0 nM 5.84
CHEMBL2158971 — EC50 = 1730.0 nM 5.76
CHEMBL2158975 — EC50 = 1810.0 nM 5.74
CHEMBL2159031 — EC50 = 2620.0 nM 5.58
CHEMBL2158974 — EC50 = 2740.0 nM 5.56
CHEMBL2158969 — EC50 = 5120.0 nM 5.29
CHEMBL2159043 — EC50 = 8710.0 nM 5.06
CHEMBL2159029 — EC50 > 10000.0 nM -
CHEMBL2159030 — EC50 > 10000.0 nM -
CHEMBL2158963 — EC50 > 10000.0 nM -
CHEMBL2159018 — EC50 > 1000.0 nM -
CHEMBL2159019 — EC50 > 1000.0 nM -