Assay Detail
Binding
CHEMBL2162510
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Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of a 2-phenyl-substituted octahydrobenzo[f]quinoline as a dopamine D₃ receptor-selective full agonist ligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.17 | 9.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2158641 | — | — | 1 | 9.03 |
| CHEMBL1224527 | — | — | 1 | 7.33 |
| CHEMBL2158636 | — | — | 1 | 6.26 |
| CHEMBL2158640 | — | — | 1 | 6.04 |
| CHEMBL1255966 | — | — | 1 | - |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2158641 | — | Ki | = | 0.94 | nM | 9.03 |
| CHEMBL1224527 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL2158636 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL2158640 | — | Ki | = | 921.0 | nM | 6.04 |
| CHEMBL1255966 | — | Ki | - | — | - | |
| CHEMBL71 | CHLORPROMAZINE | Ki | - | — | - |