Assay Detail
Binding
CHEMBL2162525
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat SGLT2 expressed in COS7 cells assessed as reduction of [14C]-AMG uptake
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationship studies of 4-benzyl-1H-pyrazol-3-yl β-d-glucopyranoside derivatives as potent and selective sodium glucose co-transporter 1 (SGLT1) inhibitors with therapeutic activity on postprandial hyperglycemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.22 | 7.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL245067 | PHLORIZIN | — | 1 | 7.02 |
| CHEMBL2159101 | — | — | 1 | 5.36 |
| CHEMBL2159102 | — | — | 1 | 5.33 |
| CHEMBL2159094 | — | — | 1 | 4.39 |
| CHEMBL2159091 | — | — | 1 | 4.00 |
| CHEMBL2160193 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL245067 | PHLORIZIN | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL2159101 | — | IC50 | = | 4370.0 | nM | 5.36 |
| CHEMBL2159102 | — | IC50 | = | 4650.0 | nM | 5.33 |
| CHEMBL2159094 | — | IC50 | = | 40800.0 | nM | 4.39 |
| CHEMBL2159091 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL2160193 | — | IC50 | - | — | - |