Assay Detail
Functional
CHEMBL2162709
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Antiproliferative activity against Shh-stimulated C57BL/6 mouse granule cell precursor after 48 hrs by [3H]thymidine incorporation assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.32 | 7.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL473417 | VISMODEGIB | 4.0 | 1 | 7.79 |
| CHEMBL2160208 | — | — | 1 | 7.78 |
| CHEMBL254129 | CYCLOPAMINE | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL473417 | VISMODEGIB | IC50 | = | 16.4 | nM | 7.79 |
| CHEMBL2160208 | — | IC50 | = | 16.6 | nM | 7.78 |
| CHEMBL254129 | CYCLOPAMINE | IC50 | = | 414.0 | nM | 6.38 |