Assay Detail
Functional
CHEMBL2163102
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at kappa opioid receptor guinea pig colon tissue
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Colon |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of a dual δ OR antagonist/μ OR agonist as a potential therapeutic for diarrhea-predominant Irritable Bowel Syndrome (IBS-d).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 5.80 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2159122 | ELUXADOLINE | 4.0 | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2159122 | ELUXADOLINE | EC50 | = | 1600.0 | nM | 5.80 |