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Assay Detail

CHEMBL2166020

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of electric eel AChE by Ellman's method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Electrophorus electricus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Acetylcholinesterase (CHEMBL4078)
Type SINGLE PROTEIN
Organism Electrophorus electricus

Publication

Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Brunhofer G, Fallarero A, Karlsson D, Batista-Gonzalez A, Shinde P, Gopi Mohan C, Vuorela P.
Bioorg Med Chem (2012) 20 : 6669 -6679
PubMed 23062825 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.19 5.56

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL12089 BERBERINE CHLORIDE 1.0 1 5.56
CHEMBL258893 CHELERYTHRINE CHLORIDE 1 5.42
CHEMBL2163795 PALMATINE CHLORIDE HYDRATE 1 5.39
CHEMBL2163792 DESOXYPEGANINE HYDROCHLORIDE HYDRATE 1 4.93
CHEMBL277642 HIMBACINE 1 4.64
CHEMBL3216788 1 -
CHEMBL2165578 PEGANOLE 1 -
CHEMBL1294 QUINIDINE 4.0 1 -
CHEMBL2163794 OXYACANTHINE SULFATE 1 -
CHEMBL405686 E6 BERBAMINE 1 -
CHEMBL464724 VERATRAMINE 1 -
CHEMBL1512936 SEVEDINDIONE 1 -
CHEMBL2163793 CATHARANTHINE BASE 1 -
CHEMBL1257131 RAUWOLSCINE HYDROCHLORIDE 1 -
CHEMBL327134 HIRSUTINE 1 -
CHEMBL2163791 VASICINE 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL12089 BERBERINE CHLORIDE IC50 = 2740.0 nM 5.56
CHEMBL258893 CHELERYTHRINE CHLORIDE IC50 = 3780.0 nM 5.42
CHEMBL2163795 PALMATINE CHLORIDE HYDRATE IC50 = 4070.0 nM 5.39
CHEMBL2163792 DESOXYPEGANINE HYDROCHLORIDE HYDRATE IC50 = 11810.0 nM 4.93
CHEMBL277642 HIMBACINE IC50 = 22720.0 nM 4.64
CHEMBL3216788 IC50 - -
CHEMBL2165578 PEGANOLE IC50 - -
CHEMBL1294 QUINIDINE IC50 - -
CHEMBL2163794 OXYACANTHINE SULFATE IC50 - -
CHEMBL405686 E6 BERBAMINE IC50 - -
CHEMBL464724 VERATRAMINE IC50 - -
CHEMBL1512936 SEVEDINDIONE IC50 - -
CHEMBL2163793 CATHARANTHINE BASE IC50 - -
CHEMBL1257131 RAUWOLSCINE HYDROCHLORIDE IC50 - -
CHEMBL327134 HIRSUTINE IC50 - -
CHEMBL2163791 VASICINE IC50 - -