Assay Detail
Binding
CHEMBL2166090
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.71 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL277120 | — | — | 1 | 7.08 |
| CHEMBL9666 | — | — | 1 | 6.61 |
| CHEMBL478 | CHLOROPHENYLPIPERAZINE | 2.0 | 1 | 6.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL277120 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL9666 | — | Ki | = | 243.0 | nM | 6.61 |
| CHEMBL478 | CHLOROPHENYLPIPERAZINE | Ki | = | 352.0 | nM | 6.45 |