Assay Detail
Binding
CHEMBL2166097
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]prazoin from rat cerebral cortex adrenergic alpha1 receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.12 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL597 | PHENTOLAMINE | 4.0 | 1 | 7.80 |
| CHEMBL494675 | — | — | 1 | 7.23 |
| CHEMBL2164338 | — | — | 1 | 6.98 |
| CHEMBL2164336 | — | — | 1 | 6.81 |
| CHEMBL2164334 | — | — | 1 | 6.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL597 | PHENTOLAMINE | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL494675 | — | Ki | = | 59.1 | nM | 7.23 |
| CHEMBL2164338 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL2164336 | — | Ki | = | 156.0 | nM | 6.81 |
| CHEMBL2164334 | — | Ki | = | 165.0 | nM | 6.78 |