Assay Detail
Binding
CHEMBL2166098
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Displacement of [3H]-8-OH-DPAT from human cloned 5HT1A receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.29 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL535832 | SEROTONIN HYDROCHLORIDE | — | 1 | 8.00 |
| CHEMBL2164341 | — | — | 1 | 7.83 |
| CHEMBL2164330 | — | — | 1 | 7.76 |
| CHEMBL2164339 | — | — | 1 | 7.50 |
| CHEMBL2164333 | — | — | 1 | 7.20 |
| CHEMBL2164331 | — | — | 1 | 7.14 |
| CHEMBL494675 | — | — | 1 | 7.00 |
| CHEMBL2164343 | — | — | 1 | 6.83 |
| CHEMBL2164336 | — | — | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL535832 | SEROTONIN HYDROCHLORIDE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL2164341 | — | Ki | = | 14.9 | nM | 7.83 |
| CHEMBL2164330 | — | Ki | = | 17.4 | nM | 7.76 |
| CHEMBL2164339 | — | Ki | = | 31.4 | nM | 7.50 |
| CHEMBL2164333 | — | Ki | = | 63.2 | nM | 7.20 |
| CHEMBL2164331 | — | Ki | = | 72.1 | nM | 7.14 |
| CHEMBL494675 | — | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL2164343 | — | Ki | = | 149.0 | nM | 6.83 |
| CHEMBL2164336 | — | Ki | = | 476.0 | nM | 6.32 |