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Assay Detail

CHEMBL2166485

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Growth inhibition of human U373 cells after 3 days by MTT assay
ChEMBL ↗
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type U-373MG ATCC
Confidence 1 — Organism
Curated By Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗
Type NON-MOLECULAR

Publication

Novel trisubstituted harmine derivatives with original in vitro anticancer activity.
Frédérick R, Bruyère C, Vancraeynest C, Reniers J, Meinguet C, Pochet L, Backlund A, Masereel B, Kiss R, Wouters J.
J Med Chem (2012) 55 : 6489 -6501
PubMed 22770529 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 49 5.56 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2164698 — — 1 7.40
CHEMBL2164400 — — 1 6.70
CHEMBL2164700 — — 1 6.66
CHEMBL2164696 — — 1 6.43
CHEMBL2164705 — — 1 6.42
CHEMBL2164703 — — 1 6.41
CHEMBL2164402 — — 1 6.41
CHEMBL2164399 — — 1 6.40
CHEMBL2164710 — — 1 6.40
CHEMBL2164702 — — 1 6.39
CHEMBL2164693 — — 1 6.37
CHEMBL2164716 — — 1 6.36
CHEMBL2164717 — — 1 6.30
CHEMBL2164694 — — 1 6.30
CHEMBL2164691 — — 1 6.22
CHEMBL2164718 — — 1 6.22
CHEMBL2164401 — — 1 6.16
CHEMBL2164404 — — 1 6.10
CHEMBL2164704 — — 1 6.06
CHEMBL2164692 — — 1 6.05
CHEMBL2164697 — — 1 5.85
CHEMBL2164398 — — 1 5.77
CHEMBL2164719 — — 1 5.70
CHEMBL1645553 — — 1 5.60
CHEMBL2164720 — — 1 5.60
CHEMBL2164699 — — 1 5.60
CHEMBL2164695 — — 1 5.54
CHEMBL2164701 — — 1 5.47
CHEMBL2164715 — — 1 5.41
CHEMBL2164707 — — 1 5.13

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2164698 — IC50 = 40.0 nM 7.40
CHEMBL2164400 — IC50 = 200.0 nM 6.70
CHEMBL2164700 — IC50 = 220.0 nM 6.66
CHEMBL2164696 — IC50 = 370.0 nM 6.43
CHEMBL2164705 — IC50 = 380.0 nM 6.42
CHEMBL2164703 — IC50 = 390.0 nM 6.41
CHEMBL2164402 — IC50 = 390.0 nM 6.41
CHEMBL2164399 — IC50 = 400.0 nM 6.40
CHEMBL2164710 — IC50 = 400.0 nM 6.40
CHEMBL2164702 — IC50 = 410.0 nM 6.39
CHEMBL2164693 — IC50 = 430.0 nM 6.37
CHEMBL2164716 — IC50 = 440.0 nM 6.36
CHEMBL2164694 — IC50 = 500.0 nM 6.30
CHEMBL2164717 — IC50 = 500.0 nM 6.30
CHEMBL2164718 — IC50 = 600.0 nM 6.22
CHEMBL2164691 — IC50 = 600.0 nM 6.22
CHEMBL2164401 — IC50 = 700.0 nM 6.16
CHEMBL2164404 — IC50 = 800.0 nM 6.10
CHEMBL2164704 — IC50 = 880.0 nM 6.06
CHEMBL2164692 — IC50 = 900.0 nM 6.05
CHEMBL2164697 — IC50 = 1400.0 nM 5.85
CHEMBL2164398 — IC50 = 1700.0 nM 5.77
CHEMBL2164719 — IC50 = 2000.0 nM 5.70
CHEMBL2164699 — IC50 = 2500.0 nM 5.60
CHEMBL2164720 — IC50 = 2500.0 nM 5.60
CHEMBL1645553 — IC50 = 2500.0 nM 5.60
CHEMBL2164695 — IC50 = 2900.0 nM 5.54
CHEMBL2164701 — IC50 = 3400.0 nM 5.47
CHEMBL2164715 — IC50 = 3900.0 nM 5.41
CHEMBL2164707 — IC50 = 7400.0 nM 5.13
CHEMBL1645548 — IC50 = 7500.0 nM 5.12
CHEMBL2164403 — IC50 = 9000.0 nM 5.05
CHEMBL1645550 — IC50 = 9100.0 nM 5.04
CHEMBL1645549 — IC50 = 9300.0 nM 5.03
CHEMBL2164709 — IC50 = 18000.0 nM 4.75
CHEMBL1645551 — IC50 = 21000.0 nM 4.68
CHEMBL1645552 — IC50 = 24000.0 nM 4.62
CHEMBL1645545 — IC50 = 24000.0 nM 4.62
CHEMBL2164714 — IC50 = 26000.0 nM 4.58
CHEMBL2164706 — IC50 = 27000.0 nM 4.57
CHEMBL2164711 — IC50 = 30000.0 nM 4.52
CHEMBL2164712 — IC50 = 31000.0 nM 4.51
CHEMBL1645544 — IC50 = 32000.0 nM 4.50
CHEMBL269538 HARMINE IC50 = 32000.0 nM 4.50
CHEMBL2164713 — IC50 = 33000.0 nM 4.48
CHEMBL14355 — IC50 = 42000.0 nM 4.38
CHEMBL1645546 — IC50 = 64000.0 nM 4.19
CHEMBL2164708 — IC50 = 80000.0 nM 4.10
CHEMBL1645547 — IC50 > 100000.0 nM -