Assay Detail
Functional
CHEMBL2167031
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Inhibition of LPS-stimulated TNFalpha production in human Whole blood
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
4-Phenyl-7-azaindoles as potent, selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.03 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2164412 | — | — | 1 | 6.60 |
| CHEMBL2164411 | — | — | 1 | 6.60 |
| CHEMBL483165 | — | — | 1 | 6.40 |
| CHEMBL2164410 | — | — | 1 | 6.40 |
| CHEMBL2164417 | — | — | 1 | 6.40 |
| CHEMBL2164426 | — | — | 1 | 6.30 |
| CHEMBL2164413 | — | — | 1 | 6.20 |
| CHEMBL2164415 | — | — | 1 | 6.20 |
| CHEMBL2164424 | — | — | 1 | 6.00 |
| CHEMBL2164425 | — | — | 1 | 6.00 |
| CHEMBL2164423 | — | — | 1 | 6.00 |
| CHEMBL2164418 | — | — | 1 | 6.00 |
| CHEMBL2164427 | — | — | 1 | 5.90 |
| CHEMBL2164416 | — | — | 1 | 5.90 |
| CHEMBL2164414 | — | — | 1 | 5.90 |
| CHEMBL2164422 | — | — | 1 | 5.90 |
| CHEMBL2164421 | — | — | 1 | 5.80 |
| CHEMBL483557 | — | — | 1 | 5.60 |
| CHEMBL2164420 | — | — | 1 | 5.60 |
| CHEMBL2164419 | — | — | 1 | 5.50 |
| CHEMBL520308 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2164412 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL2164411 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL483165 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL2164410 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL2164417 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL2164426 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL2164413 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL2164415 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL2164424 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2164425 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2164423 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2164418 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2164427 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL2164416 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL2164414 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL2164422 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL2164421 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL483557 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL2164420 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL2164419 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL520308 | — | IC50 | = | 3162.28 | nM | 5.50 |