Assay Detail
Functional
CHEMBL2167059
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human KBVIN cells overexpressing P-gp after 2 hrs by methylene blue staining-based spectrophotometric analysis
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KBVIN |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.38 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL228286 | (-)-ANTOFINE | — | 1 | 7.60 |
| CHEMBL2164800 | — | — | 1 | 7.60 |
| CHEMBL2164804 | — | — | 1 | 7.60 |
| CHEMBL2164798 | — | — | 1 | 7.37 |
| CHEMBL2164802 | — | — | 1 | 7.35 |
| CHEMBL2164791 | — | — | 1 | 7.18 |
| CHEMBL2164799 | — | — | 1 | 7.11 |
| CHEMBL2164805 | — | — | 1 | 6.92 |
| CHEMBL2164795 | — | — | 1 | 6.37 |
| CHEMBL2164796 | — | — | 1 | 6.19 |
| CHEMBL2164793 | — | — | 1 | 6.19 |
| CHEMBL2164808 | — | — | 1 | 6.06 |
| CHEMBL2164801 | — | — | 1 | 5.83 |
| CHEMBL2164797 | — | — | 1 | 5.66 |
| CHEMBL2164806 | — | — | 1 | 5.66 |
| CHEMBL2164794 | — | — | 1 | 5.58 |
| CHEMBL2164803 | — | — | 1 | 5.51 |
| CHEMBL2164792 | — | — | 1 | 5.47 |
| CHEMBL2164809 | — | — | 1 | 5.43 |
| CHEMBL2164807 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL228286 | (-)-ANTOFINE | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2164800 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2164804 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2164798 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL2164802 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL2164791 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL2164799 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL2164805 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2164795 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL2164796 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL2164793 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL2164808 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL2164801 | — | IC50 | = | 1479.0 | nM | 5.83 |
| CHEMBL2164797 | — | IC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL2164806 | — | IC50 | = | 2170.0 | nM | 5.66 |
| CHEMBL2164794 | — | IC50 | = | 2640.0 | nM | 5.58 |
| CHEMBL2164803 | — | IC50 | = | 3070.0 | nM | 5.51 |
| CHEMBL2164792 | — | IC50 | = | 3420.0 | nM | 5.47 |
| CHEMBL2164809 | — | IC50 | = | 3690.0 | nM | 5.43 |
| CHEMBL2164807 | — | IC50 | = | 12560.0 | nM | 4.90 |