Assay Detail
Binding
CHEMBL2167306
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Binding affinity to Aurora kinase B catalytic domain by competition binding assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of highly potent and selective pan-Aurora kinase inhibitors with enhanced in vivo antitumor therapeutic index.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 28 | 8.43 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2163404 | — | — | 1 | 8.77 |
| CHEMBL2163407 | — | — | 1 | 8.77 |
| CHEMBL2163394 | — | — | 1 | 8.72 |
| CHEMBL2163402 | — | — | 1 | 8.72 |
| CHEMBL2163388 | — | — | 1 | 8.66 |
| CHEMBL2163398 | — | — | 1 | 8.62 |
| CHEMBL2163403 | — | — | 1 | 8.60 |
| CHEMBL2163390 | — | — | 1 | 8.59 |
| CHEMBL2163410 | — | — | 1 | 8.54 |
| CHEMBL2163392 | — | — | 1 | 8.54 |
| CHEMBL2163389 | — | — | 1 | 8.54 |
| CHEMBL2163387 | — | — | 1 | 8.51 |
| CHEMBL2163408 | — | — | 1 | 8.51 |
| CHEMBL2163400 | — | — | 1 | 8.51 |
| CHEMBL2163396 | — | — | 1 | 8.49 |
| CHEMBL2163395 | — | — | 1 | 8.48 |
| CHEMBL2163412 | — | — | 1 | 8.44 |
| CHEMBL2163391 | — | — | 1 | 8.43 |
| CHEMBL2163411 | — | — | 1 | 8.43 |
| CHEMBL2163401 | — | — | 1 | 8.37 |
| CHEMBL2163413 | — | — | 1 | 8.24 |
| CHEMBL2163397 | — | — | 1 | 8.21 |
| CHEMBL2163409 | — | — | 1 | 8.18 |
| CHEMBL2163406 | — | — | 1 | 8.18 |
| CHEMBL2163393 | — | — | 1 | 8.16 |
| CHEMBL1822658 | — | — | 1 | 8.10 |
| CHEMBL2163399 | — | — | 1 | 7.85 |
| CHEMBL2163405 | — | — | 1 | 7.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2163404 | — | Kd | = | 1.7 | nM | 8.77 |
| CHEMBL2163407 | — | Kd | = | 1.7 | nM | 8.77 |
| CHEMBL2163394 | — | Kd | = | 1.9 | nM | 8.72 |
| CHEMBL2163402 | — | Kd | = | 1.9 | nM | 8.72 |
| CHEMBL2163388 | — | Kd | = | 2.2 | nM | 8.66 |
| CHEMBL2163398 | — | Kd | = | 2.4 | nM | 8.62 |
| CHEMBL2163403 | — | Kd | = | 2.5 | nM | 8.60 |
| CHEMBL2163390 | — | Kd | = | 2.6 | nM | 8.59 |
| CHEMBL2163410 | — | Kd | = | 2.9 | nM | 8.54 |
| CHEMBL2163392 | — | Kd | = | 2.9 | nM | 8.54 |
| CHEMBL2163389 | — | Kd | = | 2.9 | nM | 8.54 |
| CHEMBL2163387 | — | Kd | = | 3.1 | nM | 8.51 |
| CHEMBL2163408 | — | Kd | = | 3.1 | nM | 8.51 |
| CHEMBL2163400 | — | Kd | = | 3.1 | nM | 8.51 |
| CHEMBL2163396 | — | Kd | = | 3.2 | nM | 8.49 |
| CHEMBL2163395 | — | Kd | = | 3.3 | nM | 8.48 |
| CHEMBL2163412 | — | Kd | = | 3.6 | nM | 8.44 |
| CHEMBL2163391 | — | Kd | = | 3.7 | nM | 8.43 |
| CHEMBL2163411 | — | Kd | = | 3.7 | nM | 8.43 |
| CHEMBL2163401 | — | Kd | = | 4.3 | nM | 8.37 |
| CHEMBL2163413 | — | Kd | = | 5.7 | nM | 8.24 |
| CHEMBL2163397 | — | Kd | = | 6.1 | nM | 8.21 |
| CHEMBL2163409 | — | Kd | = | 6.6 | nM | 8.18 |
| CHEMBL2163406 | — | Kd | = | 6.6 | nM | 8.18 |
| CHEMBL2163393 | — | Kd | = | 6.9 | nM | 8.16 |
| CHEMBL1822658 | — | Kd | = | 8.0 | nM | 8.10 |
| CHEMBL2163399 | — | Kd | = | 14.2 | nM | 7.85 |
| CHEMBL2163405 | — | Kd | = | 14.8 | nM | 7.83 |