Assay Detail
Binding
CHEMBL2167349
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Inhibition of GCS in human A549 cells assessed as decrease in GM1 synthesis after 72 hrs by Fluorescence assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and characterization of an inhibitor of glucosylceramide synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.76 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1911679 | — | — | 1 | 8.70 |
| CHEMBL2163825 | — | — | 1 | 8.70 |
| CHEMBL1911678 | — | — | 1 | 8.70 |
| CHEMBL2163833 | — | — | 1 | 8.52 |
| CHEMBL2163832 | — | — | 1 | 8.40 |
| CHEMBL2163829 | — | — | 1 | 8.22 |
| CHEMBL2163827 | — | — | 1 | 8.10 |
| CHEMBL2163839 | — | — | 1 | 8.00 |
| CHEMBL2163834 | — | — | 1 | 7.85 |
| CHEMBL2163828 | — | — | 1 | 7.82 |
| CHEMBL2163826 | — | — | 1 | 7.40 |
| CHEMBL2163838 | — | — | 1 | 6.92 |
| CHEMBL2163830 | — | — | 1 | 6.48 |
| CHEMBL574645 | — | — | 1 | 4.78 |
| CHEMBL2163824 | — | — | 1 | - |
| CHEMBL2163823 | — | — | 1 | - |
| CHEMBL2163822 | — | — | 1 | - |
| CHEMBL2163837 | — | — | 1 | - |
| CHEMBL2163836 | — | — | 1 | - |
| CHEMBL2163835 | — | — | 1 | - |
| CHEMBL2163831 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1911679 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2163825 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1911678 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2163833 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2163832 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2163829 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2163827 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2163839 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2163834 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2163828 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2163826 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2163838 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2163830 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL574645 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL2163824 | — | IC50 | - | — | - | |
| CHEMBL2163823 | — | IC50 | - | — | - | |
| CHEMBL2163822 | — | IC50 | - | — | - | |
| CHEMBL2163837 | — | IC50 | - | — | - | |
| CHEMBL2163836 | — | IC50 | - | — | - | |
| CHEMBL2163835 | — | IC50 | - | — | - | |
| CHEMBL2163831 | — | IC50 | - | — | - |