Assay Detail
Binding
CHEMBL2167350
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Inhibition of GCS assessed as amount of UDP glucose after 3 hrs by Fluorometry analysis
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery and characterization of an inhibitor of glucosylceramide synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.72 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2163838 | — | — | 1 | 8.70 |
| CHEMBL2163828 | — | — | 1 | 8.70 |
| CHEMBL2163821 | — | — | 1 | 8.70 |
| CHEMBL2163827 | — | — | 1 | 8.52 |
| CHEMBL2163826 | — | — | 1 | 8.52 |
| CHEMBL2163823 | — | — | 1 | 8.52 |
| CHEMBL2163825 | — | — | 1 | 8.40 |
| CHEMBL2163839 | — | — | 1 | 8.40 |
| CHEMBL2163834 | — | — | 1 | 8.15 |
| CHEMBL1911678 | — | — | 1 | 8.05 |
| CHEMBL2163829 | — | — | 1 | 8.00 |
| CHEMBL2163833 | — | — | 1 | 8.00 |
| CHEMBL2163832 | — | — | 1 | 7.92 |
| CHEMBL2163824 | — | — | 1 | 7.80 |
| CHEMBL1911679 | — | — | 1 | 7.80 |
| CHEMBL2163836 | — | — | 1 | 7.70 |
| CHEMBL574645 | — | — | 1 | 7.05 |
| CHEMBL2163830 | — | — | 1 | 7.05 |
| CHEMBL2163835 | — | — | 1 | 6.82 |
| CHEMBL2163831 | — | — | 1 | 6.80 |
| CHEMBL2163837 | — | — | 1 | 6.72 |
| CHEMBL2163822 | — | — | 1 | 6.58 |
| CHEMBL1029 | MIGLUSTAT | 4.0 | 1 | 4.66 |
| CHEMBL2163819 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2163838 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2163828 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2163821 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2163827 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2163826 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2163823 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2163825 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2163839 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2163834 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1911678 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2163829 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2163833 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2163832 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2163824 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1911679 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2163836 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL574645 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2163830 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2163835 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2163831 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2163837 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2163822 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1029 | MIGLUSTAT | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL2163819 | — | IC50 | > | 4000.0 | nM | - |