Assay Detail
Functional
CHEMBL2167891
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human NPFF1 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COS-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective mode of action of guanidine-containing non-peptides at human NPFF receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.61 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2165920 | — | — | 1 | 8.77 |
| CHEMBL1672380 | — | — | 1 | 7.15 |
| CHEMBL573297 | — | — | 1 | 6.28 |
| CHEMBL583068 | — | — | 1 | 5.62 |
| CHEMBL2165921 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2165920 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL1672380 | — | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL573297 | — | EC50 | = | 527.0 | nM | 6.28 |
| CHEMBL583068 | — | EC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL2165921 | — | EC50 | = | 5624.0 | nM | 5.25 |