Compound Detail
CHEMBL573297
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL573297 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VMYFCUKMGMFQNH-YIXHJXPBSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
320.0
MW (Da)
2.03
ALogP
2
HBA
3
HBD
74.3
PSA (Ų)
0.44
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 6.28
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Neuropeptide FF receptor 1 CHEMBL5951 | EC50 | 6.28 | 6.28 | 527.0 | 1 |
| Neuropeptide FF receptor 2 CHEMBL5952 | EC50 | 5.9 | 5.78 | 1258.9 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Neuropeptide FF receptor 1 | EC50 | = | 527.0 | nM | 6.28 | Agonist activity at human NPFF1 receptor expressed in COS1 cells assessed as [3H... | 22708927 |
| Neuropeptide FF receptor 2 | EC50 | = | 1258.93 | nM | 5.9 | Agonist activity at human NPFF2 receptor expressed in cells assessed as beta-gal... | 19803524 |
| Neuropeptide FF receptor 2 | EC50 | = | 2195.0 | nM | 5.66 | Agonist activity at human NPFF2 receptor expressed in COS1 cells assessed as [3H... | 22708927 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19803524 | 10.1021/jm9011998 | Neuropeptide FF receptor 2 | 2 |
| 22708927 | 10.1021/jm300535s | Neuropeptide FF receptor 2 | 2 |
| 22708927 | 10.1021/jm300535s | Neuropeptide FF receptor 1 | 2 |
| 19803524 | 10.1021/jm9011998 | Neuropeptide FF receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine