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Assay Detail

CHEMBL2168061

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Binding
Inhibition of tyrosinase using L-dihydroxyphenylalanine as substrate preincubated for 30 mins measured after 7 mins by spectrophotometric analysis
36
Total Activities
21
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Tyrosinase inhibitors from the wood of Artocarpus heterophyllus.
Nguyen NT, Nguyen MH, Nguyen HX, Bui NK, Nguyen MT.
J Nat Prod (2012) 75 : 1951 -1955
PubMed 23113717 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 4.89 7.89
Inhibition 15 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL465880 MORACHALCONE A 2 7.89
CHEMBL2164988 ALBANIN A 2 6.00
CHEMBL66879 COUMARIC ACID 2 5.64
CHEMBL2164980 ARTOCARMIN B 2 5.08
CHEMBL441343 PARABEN 2 5.03
CHEMBL518543 KUWANON C 2 4.76
CHEMBL2164979 ARTOCARMIN A 2 4.73
CHEMBL2164985 ARTOCARMITIN C 2 4.69
CHEMBL485777 CUDRAFLAVONE C 2 4.67
CHEMBL2164981 2 4.40
CHEMBL287556 KOJIC ACID 1 4.35
CHEMBL2164982 2 4.33
CHEMBL497716 GEMICHALCONE B 2 4.26
CHEMBL2164984 2 4.18
CHEMBL2164987 GEMICHALCONE A 2 4.13
CHEMBL517334 ISOGEMICHALCONE B 2 4.08
CHEMBL2164978 GOLDFUSSINOL 1 -
CHEMBL120568 VANILLIC ACID 1 -
CHEMBL328910 2,4-DIHYDROXYBENZOIC ACID 1 -
CHEMBL2164986 1 -
CHEMBL2164983 ARTOCARMITIN A 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL465880 MORACHALCONE A IC50 = 13.0 nM 7.89
CHEMBL2164988 ALBANIN A IC50 = 1010.0 nM 6.00
CHEMBL66879 COUMARIC ACID IC50 = 2300.0 nM 5.64
CHEMBL2164980 ARTOCARMIN B IC50 = 8400.0 nM 5.08
CHEMBL441343 PARABEN IC50 = 9300.0 nM 5.03
CHEMBL518543 KUWANON C IC50 = 17300.0 nM 4.76
CHEMBL2164979 ARTOCARMIN A IC50 = 18700.0 nM 4.73
CHEMBL2164985 ARTOCARMITIN C IC50 = 20600.0 nM 4.69
CHEMBL485777 CUDRAFLAVONE C IC50 = 21400.0 nM 4.67
CHEMBL2164981 IC50 = 40000.0 nM 4.40
CHEMBL287556 KOJIC ACID IC50 = 44600.0 nM 4.35
CHEMBL2164982 IC50 = 47300.0 nM 4.33
CHEMBL497716 GEMICHALCONE B IC50 = 55300.0 nM 4.26
CHEMBL2164984 IC50 = 66200.0 nM 4.18
CHEMBL2164987 GEMICHALCONE A IC50 = 73600.0 nM 4.13
CHEMBL517334 ISOGEMICHALCONE B IC50 = 82200.0 nM 4.08
CHEMBL2164984 Inhibition - % -
CHEMBL2164978 GOLDFUSSINOL IC50 > 100000.0 nM -
CHEMBL2164979 ARTOCARMIN A Inhibition - % -
CHEMBL2164980 ARTOCARMIN B Inhibition - % -
CHEMBL2164981 Inhibition - % -
CHEMBL2164982 Inhibition - % -
CHEMBL2164985 ARTOCARMITIN C Inhibition - % -
CHEMBL328910 2,4-DIHYDROXYBENZOIC ACID IC50 > 100000.0 nM -
CHEMBL2164987 GEMICHALCONE A Inhibition - % -
CHEMBL517334 ISOGEMICHALCONE B Inhibition - % -
CHEMBL465880 MORACHALCONE A Inhibition - % -
CHEMBL518543 KUWANON C Inhibition - % -
CHEMBL485777 CUDRAFLAVONE C Inhibition - % -
CHEMBL2164988 ALBANIN A Inhibition - % -
CHEMBL441343 PARABEN Inhibition - % -
CHEMBL66879 COUMARIC ACID Inhibition - % -
CHEMBL497716 GEMICHALCONE B Inhibition - % -
CHEMBL120568 VANILLIC ACID IC50 > 100000.0 nM -
CHEMBL2164983 ARTOCARMITIN A IC50 > 100000.0 nM -
CHEMBL2164986 IC50 > 100000.0 nM -