Compound Detail
CHEMBL485777
CUDRAFLAVONE C Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL485777 |
| Name | CUDRAFLAVONE C |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MUUDYSFWQUSAOO-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
14
Publications
0
Known Names
Molecular Properties
422.5
MW (Da)
5.30
ALogP
6
HBA
4
HBD
111.1
PSA (Ų)
0.42
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 6.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4D CHEMBL288 | IC50 | 6.58 | 6.58 | 260.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.67 | 4.67 | 21400.0 | 1 |
| RAW264.7 CHEMBL612557 | IC50 | 4.28 | 4.255 | 52300.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4D | IC50 | = | 260.0 | nM | 6.58 | Inhibition of human PDE4D2 catalytic domain (86 to 413 residues) expressed in Es... | 29291443 |
| Unchecked | IC50 | = | 21400.0 | nM | 4.67 | Inhibition of tyrosinase using L-dihydroxyphenylalanine as substrate preincubate... | 23113717 |
| RAW264.7 | IC50 | = | 52300.0 | nM | 4.28 | Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assess... | 16643064 |
| RAW264.7 | IC50 | = | 59200.0 | nM | 4.23 | Cytotoxicity against mouse RAW264.7 cells by MTT assay | 16643064 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34546736 | 10.1021/acs.jnatprod.1c00578 | Staphylococcus aureus | 44 |
| 34546736 | 10.1021/acs.jnatprod.1c00578 | Enterococcus | 9 |
| 16643064 | 10.1021/np0600346 | RAW264.7 | 3 |
| 23113717 | 10.1021/np300576w | Unchecked | 2 |
| 34546736 | 10.1021/acs.jnatprod.1c00578 | Escherichia coli | 2 |
| 34546736 | 10.1021/acs.jnatprod.1c00578 | Acinetobacter baumannii | 2 |
| 11087602 | 10.1021/np000175m | Human immunodeficiency virus 1 | 1 |
| 11087602 | 10.1021/np000175m | CEM-SS | 1 |
| 21401118 | 10.1021/np100907d | 3T3-L1 | 1 |
| 29291443 | 10.1016/j.ejmech.2017.12.057 | 3',5'-cyclic-AMP phosphodiesterase 4D | 1 |
| 34546736 | 10.1021/acs.jnatprod.1c00578 | Vero | 1 |
| 34546736 | 10.1021/acs.jnatprod.1c00578 | Pseudomonas aeruginosa | 1 |
| 34546736 | 10.1021/acs.jnatprod.1c00578 | Klebsiella pneumoniae | 1 |
| 34546736 | 10.1021/acs.jnatprod.1c00578 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine