Assay Detail
Functional
CHEMBL976731
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Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assessed as nitrite accumulation after 20 hrs
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Prenylated flavonoids from the heartwood of Artocarpus communis with inhibitory activity on lipopolysaccharide-induced nitric oxide production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.73 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL253467 | ISOBAVACHALCONE | — | 1 | 5.19 |
| CHEMBL497716 | GEMICHALCONE B | — | 1 | 5.03 |
| CHEMBL457686 | — | — | 1 | 4.91 |
| CHEMBL465880 | MORACHALCONE A | — | 1 | 4.79 |
| CHEMBL72617 | ARTOCARPIN | — | 1 | 4.73 |
| CHEMBL496842 | — | — | 1 | 4.73 |
| CHEMBL256147 | TILARGININE | 3.0 | 1 | 4.72 |
| CHEMBL460647 | SOPHORAFLAVANONE B | — | 1 | 4.69 |
| CHEMBL499860 | GEMICHALCONES C | — | 1 | 4.62 |
| CHEMBL230558 | CUDRAFLAVONE A | — | 1 | 4.38 |
| CHEMBL485777 | CUDRAFLAVONE C | — | 1 | 4.28 |
| CHEMBL525350 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL253467 | ISOBAVACHALCONE | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL497716 | GEMICHALCONE B | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL457686 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL465880 | MORACHALCONE A | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL72617 | ARTOCARPIN | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL496842 | — | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL256147 | TILARGININE | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL460647 | SOPHORAFLAVANONE B | IC50 | = | 20400.0 | nM | 4.69 |
| CHEMBL499860 | GEMICHALCONES C | IC50 | = | 23900.0 | nM | 4.62 |
| CHEMBL230558 | CUDRAFLAVONE A | IC50 | = | 42100.0 | nM | 4.38 |
| CHEMBL485777 | CUDRAFLAVONE C | IC50 | = | 52300.0 | nM | 4.28 |
| CHEMBL525350 | — | IC50 | > | 60000.0 | nM | - |