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Assay Detail

CHEMBL2168070

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant FAAH
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Fatty-acid amide hydrolase 1 (CHEMBL2243)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of potent inhibitors of human and mouse fatty acid amide hydrolases.
Butini S, Brindisi M, Gemma S, Minetti P, Cabri W, Gallo G, Vincenti S, Talamonti E, Borsini F, Caprioli A, Stasi MA, Di Serio S, Ros S, Borrelli G, Maramai S, Fezza F, Campiani G, Maccarrone M.
J Med Chem (2012) 55 : 6898 -6915
PubMed 22779702 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 6.85 7.44

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL451909 1 7.44
CHEMBL2165094 1 6.99
CHEMBL2165083 1 6.77
CHEMBL177577 1 6.20
CHEMBL2165075 1 -
CHEMBL2165074 1 -
CHEMBL2165073 1 -
CHEMBL2165072 1 -
CHEMBL2165071 1 -
CHEMBL2165070 1 -
CHEMBL2165093 1 -
CHEMBL2165092 1 -
CHEMBL2165091 1 -
CHEMBL2165076 1 -
CHEMBL2165089 1 -
CHEMBL2165088 1 -
CHEMBL2165087 1 -
CHEMBL2165086 1 -
CHEMBL2165085 1 -
CHEMBL2165084 1 -
CHEMBL2165082 1 -
CHEMBL2165095 1 -
CHEMBL2165090 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL451909 IC50 = 36.0 nM 7.44
CHEMBL2165094 IC50 = 102.0 nM 6.99
CHEMBL2165083 IC50 = 170.0 nM 6.77
CHEMBL177577 IC50 = 628.0 nM 6.20
CHEMBL2165075 IC50 - -
CHEMBL2165074 IC50 - -
CHEMBL2165073 IC50 - -
CHEMBL2165072 IC50 - -
CHEMBL2165071 IC50 - -
CHEMBL2165070 IC50 - -
CHEMBL2165093 IC50 - -
CHEMBL2165092 IC50 - -
CHEMBL2165091 IC50 - -
CHEMBL2165076 IC50 - -
CHEMBL2165089 IC50 - -
CHEMBL2165088 IC50 - -
CHEMBL2165087 IC50 - -
CHEMBL2165086 IC50 - -
CHEMBL2165085 IC50 - -
CHEMBL2165084 IC50 - -
CHEMBL2165082 IC50 - -
CHEMBL2165095 IC50 - -
CHEMBL2165090 IC50 - -