Assay Detail
Functional
CHEMBL2168098
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Antiproliferative activity against human paclitaxel-resistant PC3-TxR cells after 48 hrs by SRB assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC3-TxR |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel 2-aryl-4-benzoyl-imidazole (ABI-III) analogues targeting tubulin polymerization as antiproliferative agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.46 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2163631 | SABIZABULIN | 3.0 | 1 | 8.43 |
| CHEMBL2163633 | — | — | 1 | 7.65 |
| CHEMBL2163632 | — | — | 1 | 7.56 |
| CHEMBL2163634 | — | — | 1 | 7.37 |
| CHEMBL2163635 | — | — | 1 | 7.01 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2163631 | SABIZABULIN | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL2163633 | — | IC50 | = | 22.4 | nM | 7.65 |
| CHEMBL2163632 | — | IC50 | = | 27.6 | nM | 7.56 |
| CHEMBL2163634 | — | IC50 | = | 42.8 | nM | 7.37 |
| CHEMBL2163635 | — | IC50 | = | 98.6 | nM | 7.01 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 188.0 | nM | 6.73 |