Assay Detail
Functional
CHEMBL2168104
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Antiproliferative activity against human A375 cells after 48 hrs by SRB assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel 2-aryl-4-benzoyl-imidazole (ABI-III) analogues targeting tubulin polymerization as antiproliferative agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.49 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2163631 | SABIZABULIN | 3.0 | 1 | 8.49 |
| CHEMBL2163633 | — | — | 1 | 7.73 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.69 |
| CHEMBL2163635 | — | — | 1 | 7.39 |
| CHEMBL2163634 | — | — | 1 | 7.27 |
| CHEMBL2163632 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2163631 | SABIZABULIN | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL2163633 | — | IC50 | = | 18.8 | nM | 7.73 |
| CHEMBL107 | COLCHICINE | IC50 | = | 20.6 | nM | 7.69 |
| CHEMBL2163635 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL2163634 | — | IC50 | = | 53.4 | nM | 7.27 |
| CHEMBL2163632 | — | IC50 | = | 414.0 | nM | 6.38 |