Assay Detail
Functional
CHEMBL2168115
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Antiviral activity against HIV1 clade B (BaL) infected in human PBMCs assessed as inhibition of p24 antigen production by ELISA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 9.33 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2163842 | — | — | 1 | 10.00 |
| CHEMBL2311028 | PLERIXAFOR OCTAHYDROCHLORIDE | — | 1 | 9.00 |
| CHEMBL256907 | MARAVIROC | 4.0 | 1 | 9.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2163842 | — | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL2311028 | PLERIXAFOR OCTAHYDROCHLORIDE | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL256907 | MARAVIROC | EC50 | = | 1.0 | nM | 9.00 |