Assay Detail
Binding
CHEMBL2168415
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]R-(-)-14 from human FLAG-tagged alpha1 GABA A receptor expressed in HEK293S cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293S |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Gamma-aminobutyric acid receptor subunit alpha-1 (CHEMBL1962) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.42 | 5.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2163548 | — | — | 1 | 5.42 |
| CHEMBL2163549 | — | — | 1 | - |
| CHEMBL448 | PENTOBARBITAL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2163548 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL2163549 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL448 | PENTOBARBITAL | IC50 | = | 1000000.0 | nM | - |