Assay Detail
Binding
CHEMBL2168444
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human liver microsome 2,3-OSC after 1 hr by Silica gel plate phosphor imaging
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cytotoxic effects of combination of oxidosqualene cyclase inhibitors with atorvastatin in human cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.04 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112210 | — | — | 1 | 8.54 |
| CHEMBL448434 | — | — | 1 | 8.30 |
| CHEMBL324162 | — | — | 1 | 8.24 |
| CHEMBL2164235 | — | — | 1 | 8.11 |
| CHEMBL481608 | — | — | 1 | 8.10 |
| CHEMBL2164234 | — | — | 1 | 8.00 |
| CHEMBL2164237 | — | — | 1 | 7.95 |
| CHEMBL2164236 | — | — | 1 | 7.90 |
| CHEMBL479464 | — | — | 1 | 7.75 |
| CHEMBL2164238 | — | — | 1 | 7.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112210 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL448434 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL324162 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL2164235 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL481608 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2164234 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2164237 | — | IC50 | = | 11.2 | nM | 7.95 |
| CHEMBL2164236 | — | IC50 | = | 12.7 | nM | 7.90 |
| CHEMBL479464 | — | IC50 | = | 17.8 | nM | 7.75 |
| CHEMBL2164238 | — | IC50 | = | 28.7 | nM | 7.54 |