Assay Detail
ADMET
CHEMBL2168458
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Cytotoxicity against human HCEC cells assessed as reduction in cell survival after 72 hrs by MTT assay
14
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HCEC |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Cytotoxic effects of combination of oxidosqualene cyclase inhibitors with atorvastatin in human cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.03 | 5.66 |
| Activity | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL479464 | — | — | 2 | 5.66 |
| CHEMBL324162 | — | — | 2 | 5.42 |
| CHEMBL112210 | — | — | 1 | 5.32 |
| CHEMBL448434 | — | — | 1 | 5.29 |
| CHEMBL2164237 | — | — | 1 | 4.72 |
| CHEMBL393220 | ATORVASTATIN CALCIUM | 4.0 | 1 | 4.69 |
| CHEMBL2164235 | — | — | 1 | 4.58 |
| CHEMBL2164234 | — | — | 1 | 4.54 |
| CHEMBL481608 | — | — | 2 | - |
| CHEMBL2164238 | — | — | 1 | - |
| CHEMBL2164236 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL479464 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL324162 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL112210 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL448434 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL2164237 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL393220 | ATORVASTATIN CALCIUM | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL2164235 | — | IC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL2164234 | — | IC50 | = | 29100.0 | nM | 4.54 |
| CHEMBL479464 | — | Activity | - | — | - | |
| CHEMBL324162 | — | Activity | - | — | - | |
| CHEMBL481608 | — | Activity | - | — | - | |
| CHEMBL2164238 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2164236 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL481608 | — | IC50 | > | 30000.0 | nM | - |