Assay Detail
Functional
CHEMBL2168459
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Cytotoxicity against human LN229 cells assessed as reduction in cell survival after 72 hrs by MTT assay
14
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LN-229 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cytotoxic effects of combination of oxidosqualene cyclase inhibitors with atorvastatin in human cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.07 | 5.54 |
| Activity | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL479464 | — | — | 2 | 5.54 |
| CHEMBL112210 | — | — | 1 | 5.28 |
| CHEMBL393220 | ATORVASTATIN CALCIUM | 4.0 | 1 | 5.09 |
| CHEMBL448434 | — | — | 1 | 5.08 |
| CHEMBL324162 | — | — | 2 | 5.06 |
| CHEMBL481608 | — | — | 2 | 4.75 |
| CHEMBL2164234 | — | — | 1 | 4.68 |
| CHEMBL2164238 | — | — | 1 | - |
| CHEMBL2164237 | — | — | 1 | - |
| CHEMBL2164236 | — | — | 1 | - |
| CHEMBL2164235 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL479464 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL112210 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL393220 | ATORVASTATIN CALCIUM | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL448434 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL324162 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL481608 | — | IC50 | = | 17900.0 | nM | 4.75 |
| CHEMBL2164234 | — | IC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL479464 | — | Activity | - | — | - | |
| CHEMBL324162 | — | Activity | - | — | - | |
| CHEMBL481608 | — | Activity | - | — | - | |
| CHEMBL2164238 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2164237 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2164236 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2164235 | — | IC50 | > | 30000.0 | nM | - |