Assay Detail
Functional
CHEMBL2168515
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Antiviral activity against R5 tropic HIV1 Ba-L infected human PBMC assessed as inhibition of viral replication by p-24 antigen specific ELISA
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Mitigating hERG Inhibition: Design of Orally Bioavailable CCR5 Antagonists as Potent Inhibitors of R5 HIV-1 Replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.68 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2164202 | — | — | 1 | 8.80 |
| CHEMBL2164207 | — | — | 1 | 8.72 |
| CHEMBL2164210 | — | — | 1 | 8.54 |
| CHEMBL2164208 | — | — | 1 | 8.32 |
| CHEMBL2164212 | — | — | 1 | 8.16 |
| CHEMBL2164209 | — | — | 1 | 8.14 |
| CHEMBL2164206 | — | — | 1 | 7.83 |
| CHEMBL2164203 | — | — | 1 | 7.81 |
| CHEMBL2164201 | — | — | 1 | 7.79 |
| CHEMBL2164220 | — | — | 1 | 7.77 |
| CHEMBL2164211 | — | — | 1 | 7.67 |
| CHEMBL2164215 | — | — | 1 | 7.65 |
| CHEMBL2164217 | — | — | 1 | 7.46 |
| CHEMBL2164219 | — | — | 1 | 7.42 |
| CHEMBL2164213 | — | — | 1 | 7.18 |
| CHEMBL2164218 | — | — | 1 | 6.86 |
| CHEMBL2164205 | — | — | 1 | 6.46 |
| CHEMBL1926888 | — | — | 1 | 5.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2164202 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL2164207 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL2164210 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL2164208 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL2164212 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL2164209 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL2164206 | — | IC50 | = | 14.8 | nM | 7.83 |
| CHEMBL2164203 | — | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL2164201 | — | IC50 | = | 16.1 | nM | 7.79 |
| CHEMBL2164220 | — | IC50 | = | 17.1 | nM | 7.77 |
| CHEMBL2164211 | — | IC50 | = | 21.3 | nM | 7.67 |
| CHEMBL2164215 | — | IC50 | = | 22.5 | nM | 7.65 |
| CHEMBL2164217 | — | IC50 | = | 34.4 | nM | 7.46 |
| CHEMBL2164219 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL2164213 | — | IC50 | = | 65.9 | nM | 7.18 |
| CHEMBL2164218 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL2164205 | — | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL1926888 | — | IC50 | = | 1832.0 | nM | 5.74 |