Assay Detail
Binding
CHEMBL2168709
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CatL assessed as suppression of enzyme-mediated Z-Phe-Arg-AMC cleavage by QFRET assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
(1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.51 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2164674 | — | — | 1 | 5.51 |
| CHEMBL2164672 | — | — | 1 | - |
| CHEMBL2163588 | — | — | 1 | - |
| CHEMBL2163587 | — | — | 1 | - |
| CHEMBL2163586 | — | — | 1 | - |
| CHEMBL2163585 | — | — | 1 | - |
| CHEMBL2163584 | — | — | 1 | - |
| CHEMBL2163583 | — | — | 1 | - |
| CHEMBL2163582 | — | — | 1 | - |
| CHEMBL2163349 | — | — | 1 | - |
| CHEMBL2163581 | — | — | 1 | - |
| CHEMBL2164690 | — | — | 1 | - |
| CHEMBL2164689 | — | — | 1 | - |
| CHEMBL2164688 | — | — | 1 | - |
| CHEMBL2163360 | — | — | 1 | - |
| CHEMBL2164671 | — | — | 1 | - |
| CHEMBL2164673 | — | — | 1 | - |
| CHEMBL2164675 | — | — | 1 | - |
| CHEMBL2164676 | — | — | 1 | - |
| CHEMBL2164677 | — | — | 1 | - |
| CHEMBL2164687 | — | — | 1 | - |
| CHEMBL2164679 | — | — | 1 | - |
| CHEMBL2164680 | — | — | 1 | - |
| CHEMBL2164681 | — | — | 1 | - |
| CHEMBL2164682 | — | — | 1 | - |
| CHEMBL2164683 | — | — | 1 | - |
| CHEMBL2164684 | — | — | 1 | - |
| CHEMBL2164685 | — | — | 1 | - |
| CHEMBL2164686 | — | — | 1 | - |
| CHEMBL2164678 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2164674 | — | IC50 | = | 3110.0 | nM | 5.51 |
| CHEMBL2163584 | — | IC50 | - | — | - | |
| CHEMBL2164688 | — | IC50 | - | — | - | |
| CHEMBL2164689 | — | IC50 | - | — | - | |
| CHEMBL2164690 | — | IC50 | - | — | - | |
| CHEMBL2163581 | — | IC50 | - | — | - | |
| CHEMBL2163349 | — | IC50 | - | — | - | |
| CHEMBL2163582 | — | IC50 | - | — | - | |
| CHEMBL2163583 | — | IC50 | - | — | - | |
| CHEMBL2164671 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL2163585 | — | IC50 | - | — | - | |
| CHEMBL2163586 | — | IC50 | - | — | - | |
| CHEMBL2163587 | — | IC50 | - | — | - | |
| CHEMBL2163588 | — | IC50 | - | — | - | |
| CHEMBL2163589 | — | IC50 | - | — | - | |
| CHEMBL2163590 | — | IC50 | - | — | - | |
| CHEMBL2163591 | — | IC50 | - | — | - | |
| CHEMBL2163360 | — | IC50 | - | — | - | |
| CHEMBL2164672 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2164673 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2164675 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL2164676 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2164677 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL2164687 | — | IC50 | - | — | - | |
| CHEMBL2164679 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2164680 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL2164681 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2164682 | — | IC50 | - | — | - | |
| CHEMBL2164683 | — | IC50 | - | — | - | |
| CHEMBL2164684 | — | IC50 | - | — | - | |
| CHEMBL2164685 | — | IC50 | - | — | - | |
| CHEMBL2164686 | — | IC50 | - | — | - | |
| CHEMBL2164678 | — | IC50 | > | 40000.0 | nM | - |