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Assay Detail

CHEMBL2168890

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]2-chloro-N6-cyclopentyladenosine from human A2AR
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Adenosine receptor A2a (CHEMBL251)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice.
Korboukh I, Hull-Ryde EA, Rittiner JE, Randhawa AS, Coleman J, Fitzpatrick BJ, Setola V, Janzen WP, Frye SV, Zylka MJ, Jin J.
J Med Chem (2012) 55 : 6467 -6477
PubMed 22738238 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 5.57 5.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2163560 1 5.80
CHEMBL2163561 1 5.33

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2163560 Ki = 1600.0 nM 5.80
CHEMBL2163561 Ki = 4700.0 nM 5.33